ApoB should be measured in all prospective and interventional studies to further support this suggestion and to optimize apoB targets. ApoB is also the promising target of LDL-lowering therapy. Therapeutic strategies directed at the hepatic assembly of VLDL (the precursor of LDL) should be explored in detail.”
“The aim of our AG-120 mw study was to identify factors that are related to a more aggressive a-cell destruction in children at presentation of type 1 diabetes mellitus (T1D).
We analyzed age, HbA1c, pH, bicarbonate, IAA, IA2, GADA, C peptide of 290 consecutive patients with T1D at onset. Seventy-three (25.2%) were younger than 4 years; 217 (74.8%) were aged 4-18 years. Younger
patients had lower C peptide, pH and bicarbonate than older ones. Age at T1D onset was negatively related to IAA titers (r: -0.3404, p < 0.001), positively related to IA2 titers (r: LOXO-101 cell line 0.1249, p: 0.03) and to C peptide (r: 0.42, p: < 0.001). Multivariable linear regression showed that C peptide was negatively related to HbA1c and positively related to age, pH at admission and IAA titers.
T1D in very young children is characterized by a more extensive beta-cell destruction, and younger age at onset is related to a more severe decompensation.”
“The abundance of caveolae in adipocytes suggests a possible cell-specific role
for these structures, and because these cells take up and release fatty acids as their quantitatively most robust activity, modulation of fatty acid movement is one such role that is supported by substantial in vitro and in vivo data. In addition, caveolae are particularly rich in cholesterol and sphingolipids, and indeed, fat cells harbor more cholesterol than any other tissue. In this article, we review the role of adipocyte caveolae with regard to these important lipid classes.”
pasting, cooking and textural properties of common and durum wheat varieties were evaluated. The effect of debranning to the extent of 4 and 8% on these properties click here was also studied. Durum wheat varieties had higher protein and lower L* value and b* values compared to common wheat. Debranning of grains increased L* value, gruel solids loss and decreased a* value, cooking time and textural parameters. Meals from debranned grains had pastes with higher peak viscosity, breakdown and final viscosity; and lower pasting temperature. Meals from whole and debranned durum wheat showed lower breakdown viscosity compared to those of common wheat. Durum wheat debranned to 4% level had better cooking and textural properties compared to that of common wheat, hence, better suited for bulgur making. (C) 2010 Elsevier Ltd. All rights reserved.”
“The nuclear lipid fraction is comprised of glycerophospholipids, sphingolipids, plasmalogens, gangliosides, cholesterol and fatty acids. Intranuclear lipid enzymes are responsible for their active metabolism completely independently from that of other cell membranes.