Danggui Buxue Decoction can enhance myocardial ischemia-reperfusion injury and heart failure, relieve signs and symptoms of diabetic cardiomyopathy, prevent pulmonary fibrosis, protect lung injury and combat lung cancer and other cardiopulmonary diseases. Preclinical studies have indicated that this prescription can inhibit inflammation and oxidative stress, regulate autophagy and enhance immune purpose through multi-target paths. Reviewing the main efficient components, pharmacological activity and apparatus, and medical application of Danggui Buxue Decoction are useful to supply extensive information for the clinical application of Danggui Buxue Decoction in prevention and treatment of cardiovascular and pulmonary diseases.The plateau is a unique environment with low-pressure, reduced air, low temperature, and large ultraviolet radiation. The exercise overall performance of individuals Medical genomics in the plateau is normally paid off, which really impacts the life span and health of people residing the plateau and entering the plateau. In the last few years, the avoidance and treatment of injury brought on by thin air hypoxia has actually drawn wide interest. This has shown that the higher the height because of the longer the duration of workout, the faster the stationing, the greater the effect on individuals sports performance. Fast entry in to the plateau and long-lasting stay-in the plateau impact on people’s explosive energy, endurance and good procedure. Improvements in medical technology permit various prevention ways to be used to acclimate to thin air surroundings. But, in vitro input techniques are costly, simple to rebound and possess limited effects. Therefore, drug avoidance and treatment solutions are obviously a far more economical option. Chemical drugs raise the effectiveness of high-altitude workout by enhancing the ischemic and hypoxic symptoms of one’s heart and brain, increasing lung ventilation and arterial oxygenation capacity, and accelerating the elimination of bad product accumulation after exercise. Single Chinese medication, Chinese patent medication, and mixture preparations can enhance workout overall performance by advertising human anatomy metabolic rate, enhancing muscle tissue stamina, improving semen microbiome resistance, and other systems. Conventional Chinese medication has actually special advantage and application possibility in increasing plateau recreations performance damage. The introduction of conventional Chinese medication (TCM) into the plateau area is fairly backward. There is too little system to assess the results of this unique environment of plateau low pressure and hypoxia on man meridians qi and blood, plus the etiology and pathogenesis of plateau hypoxic conditions. To assess the structure rules of anti-hypoxia TCM formula with data mining practices. The experimental literatures associated with high altitude hypoxia were searched in Asia National Knowledge Infrastructure (CNKI), Wanfang Med on line, VIP, Asia Biology medication disk and other databases, a standardized prescription database had been set up after evaluating and standardization of prescription information into the literary works. The structure principles among these prescription including drug regularity, medication attributes, drug efficacy, medication combination, and core prescription had been examined and displayed with aesthetic maps. Plateau hypoxia exposure triggers changes in pharmacokinetic parameters and cerebral-blood circulation of medicines, including numerous substrates of P-glycoprotein (P-gp). Levetiracetam, some sort of antiepileptic drugs, is a substrate of P-gp. Whether plateau hypoxia exposure changes its pharmacokinetic faculties DNA Damage inhibitor and cerebral-blood distribution remains confusing. This research is designed to investigate the results of plateau hypoxia regarding the pharmacokinetics and cerebra-blood circulation of levetiracetam. Wistar rats were divided in to a low-altitude control group, a high-altitude team, a solvent team, and a P-gp induction group. After 24 h of exposure at height of 4 010 m, rats in the high-altitude team were given levetiracetam orally or intravenously. The plasma was correspondingly gathered at 0.083, 0.25, 0.5, 0.83, 1.25, 2, 4, 6, 8, 10, 12, and 24 h after dental administration of the drug, while both plasma and brain had been correspondingly gathered at 5, 45, 60,120 and 240 min after intravenous injection. After 3 days adP-gp in the blood-brain barrier within the P-gp induction group had been increased by 56.3per cent ( After intense plateau hypoxia exposure, the pharmacokinetic of levetiracetam in rats tend to be altered, plus the cerebral-blood distribution of this drug in rats is decreased, which might be related to the up-regulation of P-gp phrase regarding the blood-brain barrier.After intense plateau hypoxia publicity, the pharmacokinetic of levetiracetam in rats are changed, additionally the cerebral-blood distribution of this medication in rats is decreased, that might be pertaining to the up-regulation of P-gp appearance in the blood-brain barrier. Heme chloride (Hemin) is an in vitro purified as a type of all-natural heme and an important raw product for anti-anemia and antitumor drugs. This research is designed to evaluate the safety effectation of Hemin on injury in low-pressure air chamber simulated plateau hypoxic mice, and explore its part in anti-plateau hypoxia.