11 “The first academic course dedicated to cardiac MEK162 ARRY-162 ultrasound was learnt in Indianapolis in 1968 and the first book on echocardiography published in 1972”.12 Origin of Echocardiography Edler named the technique as ultrasound cardiography (UCG). However, because echoencephalography was the only popular examination for detecting echo from the midline of the brain to see its deviation by Inhibitors,research,lifescience,medical an intracranial space–occupying lesion,11 the examination of the heart was named as echocardiography. In early years the abbreviation “echo” could not be used because of the inability to differentiate between echocardiography

and echoencephalography. However, with the disappearance of echoencephalography as a diagnostic tool, finally echocardiography was agreed as the name for this procedure.1 Currently, the abbreviation “echo” is used for echocardiography. Development of Various

Inhibitors,research,lifescience,medical Forms of Echocardiography Obviously, there have been many important developments in the field of cardiac ultrasound. They are too numerous to explain in detail. The first person who described transesophageal Inhibitors,research,lifescience,medical echocardiography (TEE) was an American.13 Japanese investigators also worked in this area, however, TEE was primarily developed in its current state by European investigators,14 and became popular after the Europeans revealed how this approach could be clinically useful.15 Doppler has a similar story. The Japanese most unique contribution to this area was the development of color flow Doppler. Although, the first paper about color flow Doppler was credited by the University of Washington in Seattle.16 Then, Hatle,17 showed that using Doppler echocardiography, hemodynamic data could be determined correctly. Contrast

echocardiography began Inhibitors,research,lifescience,medical at the University of Rochester by Gramiak and Shah during an accidental observation with the creation of large Inhibitors,research,lifescience,medical clouds of echoes within the heart after the injection of indocyanine green dye.18 Contrast echocardiography has become an important diagnostic tool for the detection of left ventricular endocardial borders.19 The implication of contrast echocardiography for detecting right-to-left shunts was reported by the Mayo Clinic group.20 Currently, there are commercial contrast agents which can pass through Dacomitinib the pulmonary capillaries and are visible on the left side of the heart.21 Three-dimensional echocardiography, intracardiac echo, myocardial velocity imaging, and 2D strain imaging were developed sequentially. Considerably increased applications of echocardiography along with the availability of Vorinostat side effects portable machines, has made echocardiography even more noticeable in clinical practice.11 M-Mode Echocardiography M-mode echocardiography was the first developed form of cardiac ultrasound (figure 1), in which a single ultrasonic beam was directed toward the heart and reflected signals were displayed on a oscillograph.