01). No changes in K(LV) were observed in controls after 3 months (0.192 +/- 0.115 from 0.195 +/- 0.121 mm Hg/mL).
Conclusions: In heart failure, left ventricular diastolic stiffness is related to neurohormonal derangement
and is modified by physical training. This improvement in LV compliance Could result front a combination of hemodynamic improvement and regression of the fibrotic process. (J Cardiac Fail 2009;15:327-333)”
“Two new dammarane-type compounds were isolated from the leaves OICR-9429 nmr and stems of Panax quinquefolium L. The new compounds were named as pseudo-ginsenoside RT6 (1) and pseudoginsengenin R-1 (2). The structures of the new compounds were elucidated by the combined analysis of NMR and HR-ESI-MS as (20S,24R)-6-O–d-glucopyranosyl-dammar-3-one-20,24-epoxy-6,12,25-triol (1) and (20S,24R)-dammar-3-one-20,24-epoxy-6,12,25-triol (2).”
“Objectives: To determine how often pharmacists inquire about patients’ complementary and alternative medicine (CAM) use, actions taken in response to patients’ CAM use, and demographic or professional characteristics that predict differences in pharmacists’ actions.
Methods: A survey was mailed to 400 randomly selected community pharmacists who resided in Texas-Mexico border cities.
Results: Most (63.8%) pharmacists had encountered patients who were using CAM. They documented CAM use AZ 628 in 9.8% of cases and monitored for drug-related problems
in 39.4%. Among users, pharmacists sometimes to usually Volasertib Cell Cycle inhibitor (3.4 +/- 1.4 [mean +/- SD]) took actions such as referring patients to
their physicians. Pharmacists were not particularly comfortable (3.2 +/- 1.0) with responding to CAM inquiries but believed patients needed adequate CAM knowledge. Pharmacists rarely to sometimes (2.6 +/- 1.2) asked patients about their CAM use. Inquiry about CAM use was greater when information could be documented in profiles (F = 4.29, P = 0.02) and when pharmacists had additional training in CAM (t = -2.59, P = 0.01). Also, in pharmacies that stocked herbal or homeopathic products, pharmacists were more likely to recommend other CAM therapies appropriate for patients’ conditions (t = -3.27, P < 0.01).
Conclusion: Pharmacists were not very proactive in inquiring about CAM use, and their actions (e.g., referral to physician) were somewhat passive. More routine inquiry and documentation are needed. Pharmacists should routinely ask about and document CAM use by patients in order to optimize drug therapy outcomes.”
“Background: Distance walked in the 6-minute walk test (6MWT) is an important prognostic parameter used clinically to assess functional status in patients with chronic heart failure (CHF). In this study, we investigated if alternative performance parameters with similar prognostic value can be gained from accelerometers.
Methods and Results: Fifty CHF patients (age, 60.9 +/- 14.