1%) in the nonsecond resection group. The concordance rate of second resection with final pathology was r = 0.810 (P < 0.01). The sensitivity and specificity

of second resection for T-2 disease were 90.9% and 98.0%, respectively, and the positive and negative predictive values of second resection for T-2 disease were 90.0% and 96.2%, respectively. Among the 94 patients followed up, those in the second resection group had significantly higher 2-year recurrence-free survival rate (77.0% Daporinad mw vs 45.8%, P = 0.025), but there was no difference in progression-free survival rate.

Conclusions: Immediate second resection of the tumor bed after complete TUR improves the effectiveness of resection by immediately confirming the presence of MP in the specimen and accurately differentiating muscle-invasive disease. The advantages of immediate second resection were precise prediction of final pathology results and reduced early recurrence.”
“Introduction: Uninterrupted chest compressions are a key factor in determining resuscitation success. Interruptions to chest compression are often associated with defibrillation, particularly the need to stand clear from the patient during defibrillation. It has been suggested that clinical examination gloves may provide adequate electrical resistance to enable safe hands-on

defibrillation in order to minimise interruptions. We therefore examined whether commonly used nitrile clinical examination gloves HIF inhibitor review provide adequate resistance to current flow to enable safe hands-on defibrillation.

Methods: Clinical examination gloves (Kimberly Clark KC300 Sterling nitrile) C59 Wnt chemical structure worn by members of hospital cardiac arrest teams were collected immediately following termination of resuscitation. To determine the level of protection afforded by visually intact gloves, electrical resistance across the glove was measured by applying a DC voltage across the glove and measuring subsequent resistance.

Results: Forty new unused gloves (control) were compared with 28 clinical (non-CPR)

gloves and 128 clinical (CPR) gloves. One glove in each group had a visible tear and was excluded from analysis. Control gloves had a minimum resistance of 120 k Omega (median 190 k Omega) compared with 60 k Omega in clinical gloves (both CPR (median 140 k Omega) and non-CPR groups (median 160 k Omega)).

Discussion: Nitrile clinical examination gloves do not provide adequate electrical insulation for the rescuer to safely undertake ‘hands-on’ defibrillation and when exposed to the physical forces of external chest compression, even greater resistive degradation occurs. Further work is required to identify gloves suitable for safe use for ‘hands-on’ defibrillation. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Kruppel-like factor 8 (KLF8) is a young member of the KLF transcription factor family proteins.