7%, and local infection in 0.8%.

CONCLUSION: The rate of serious complications from external lumbar drainage for normal pressure hydrocephalus is low. It is hoped that continued evaluation of the procedure will lead to further reductions in the complication rate.”
“Glutathione CDK inhibitor S-transferases (GSTs) are phase II detoxification enzymes involved in the metabolism of carcinogens and anticancer drugs, known also

to interact with kinase complexes during oxidative or chemical stress-induced apoptosis. We were interested whether their polymorphic variants may account for differences in outcome of patients with acute myeloid leukemia (AML) following chemotherapy. We studied the prognostic role of polymorphisms in three GST genes (GSTP1/M1/T1) in a large patient cohort Fedratinib of the German Austrian Acute Myeloid

Leukemia Study Group, treated according to prospective multicenter clinical trials (AML HD98A: 254 patients; AML HD98-B: 100 patients), with a median follow-up of 46 months. Looking at short-term adverse drug reactions, homozygous carriers of the GSTP1*105 Val allele had a faster neutrophil and platelet recovery (P = 0.002 and 0.02, respectively) and a reduced need of red cell and platelet transfusions (P = 0.01 and 0.03, respectively). Response to induction chemotherapy did not vary according to GST polymorphisms. Multivariable Cox regression models revealed a significant better relapse-free (RFS) and overall survival for the GSTP1* 105 Val (P = 0.003 and 0.03, respectively), whereas GSTT1 and GSTM1 genotypes had no significant impact. The favorable impact of GSTP1* 105 Val on RFS seems to be restricted to the subgroup of patients exhibiting a normal karyotype.”
“CEREBRAL CONVOLUTIONS WERE unknown until the 17th century. A constant sulcus was not recognized until the mid-1600s; it was named “”the fissure of Sylvius,”" after the person who had always been considered as the one who discovered it. It is commonly asserted that the first description of the lateral scissure was made by Caspar Bartholin,

who attributed its discovery to Sylvius. However, this was not actually the case, as Caspar Bartholin died in 1629, whereas Sylvius started studying medicine in 1632. The description Fedratinib ic50 could have been made either by Caspar Bartholin’s son Thomas or by Sylvius himself. Irrespective of the description’s author, the key to the history of the lateral fissure is that it was first identified by Fabrici d’Acquapendente in 1600, 40 years before Sylvius’ description. In one of the 300 colored plates (Tabulae Pictae) by Fabrici, the lateral fissure is perfectly depicted, as are the temporal convolutions. Therefore, even if it was an accidental discovery, Fabrici should be the one noted as having discovered the fissure. This article ends with a short history of the plates.