76). Any adverse events that occurred during training (including minor events such as delayed onset muscle soreness) were recorded by the student mentor in the participant’s exercise

log book. At the beginning and end of each session the student mentor asked the participant if they had experienced any injuries or other problems. Intention to treat analysis was performed and outcomes were analysed using ANCOVA with the baseline measure of each variable used as the covariate (Vickers 2005). Where data were missing, the carry-forward technique was used, which assumes that missing data remained constant (Hollis and Campbell 1999). The mean difference within each group and between the groups and their 95% CI were calculated. Standardised mean differences (SMD) (otherwise known as effect sizes) were also calculated. SMDs click here were calculated by subtracting the mean of the control group from the mean of the experimental group and dividing by the pooled standard deviation.

The SMDs were interpreted as follows: less than 0.2 was considered small, between 0.2 and 0.5 was considered moderate, and greater than 0.8 was considered large (Cohen 1977). Twenty-three adolescents (17 boys, 6 girls) with Down syndrome participated in the trial (Table 1). The participants had a mean age of 15.6 years (SD 1.6) and a mean body mass index of 24.7 kg/m2 (SD 3.8, range 19.8 to 35.0). Eleven participants were randomly allocated to the experimental group and 12 participants to the control group. There were no apparent PARP inhibitor differences at baseline between the groups for most of the demographic factors or outcome measures STK38 (Tables 1 and 2). However, the proportion of adolescents with moderate/severe intellectual disability appeared to be greater in the

experimental group compared with the control group. Participants attended 90% (198/220) of the scheduled training sessions. No serious adverse events were recorded. Missed sessions were due to illness or vacation time. None of the sessions was missed due to soreness, injury, or illness as a result of the training program. Four participants complained of mild muscle soreness during training, mostly during the early weeks of the program and all recovered spontaneously. Three participants complained of sore hands as a result of using the weight equipment; one participant resolved this by wearing gloves during training. Over the course of the training program, the experimental group progressed the amount of resistance lifted for each of the prescribed exercises by at least 95% of the initial training resistance. One participant in the control group was unavailable for reassessment but this participant was included in the intention to treat analysis via the carry-forward approach (Fig. 1). The average baseline 1RM for leg press was 88 kg, approximately 15% less than values for adolescents with typical development (Christou et al 2006).