Abnormally high RABEX-5 expression has been implicated in breast

Abnormally high RABEX-5 expression has been implicated in breast cancer and colorectal cancer, but the function

of RABEX-5 in prostate cancer has not been well studied. To date, an association between RABEX-5 expression and prostate cancer has not been reported. Therefore, reverse transcription polymerase chain reaction analysis was performed on paired samples of prostate cancer tissue and noncancerous tissue adjacent to the cancer lesion isolated from the same patient. Our data showed that there is an elevation in RABEX-5 mRNA expression in prostate cancer tissues compared to adjacent noncancerous tissues. We next BIIB057 order investigated the associations between abnormal RABEX-5 mRNA expression and clinicopathological factors. High

expression of RABEX-5 mRNA was found to significantly correlate with lymph node metastasis, clinical A-1155463 stage, preoperative prostate-specific antigen, biochemical recurrence, and Gleason score. In contrast, there were no significant correlations between abnormal RABEX-5 mRNA expression and age, surgical margin status, seminal vesicle invasion, and angiolymphatic invasion. This is the first study to elucidate the clinicopathological significance of RABEX-5 mRNA expression in patients with prostate cancer. In the present study we also have investigated the prognostic impact of RABEX-5 mRNA in a previously described cohort of 180 surgically resected prostate cancer patients [12–14]. To confirm the representativeness of the prostate cancer in present study, we analyzed established prognostic predictors of prostate cancer patient survival. Sclareol The data showed a significant impact of well-known clinical pathological prognostic parameters, such as seminal vesicle invasion, and Gleason score. Assessment of biochemical recurrence free Brigatinib cell line survival in prostate cancer revealed that the high expression

level of RABEX-5 mRNA was correlated with adverse biochemical recurrence free survival of prostate cancer patients. Since variables observed to have a prognostic influence by univariate analysis may covariate, the expression of RABEX-5 mRNA and those clinicalopathological parameters that were significant in univariate analysis were further examined in multivariate analysis. Multivariate analysis revealed that RABEX-5 mRNA expression was an independent predictor of biochemical recurrence free survival. Our data demonstrate a marked increase in RABEX-5 mRNA expression in tumors compared to noncancerous tissue, with a significant and independent relationship between high RABEX-5 mRNA expressing tumors and reduced postoperative overall survival. It seems convincing that the high RABEX-5 mRNA expression conferred a very unfavorable prognosis in our study cohort. The high expression of RABEX-5 mRNA was a significant indicator for predicting poor outcome after radical prostatectomy.

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