As a result, our study suggested that birth weight may be related to umbilical blood cord lipid levels. The cholesterol levels in umbilical cord blood were lower than those in adults. Since total cholesterol increases after birth, it is possible that the total cholesterol levels of preterm neonates are similar to or lower than those
in full term newborns. However, our results showed the cholesterol levels of the premature group were substantially higher than those of the full term group, which is in agreement with a previous report [8]. Moreover, our study indicated that this difference exists even though the premature neonates were BIBF 1120 in vivo near full term, with a gestational age between 35 and 36.6 weeks. Pardo et al. [29] used atherogenic indices and showed that the AIP did not differ between genders, but preterm newborns had higher levels than full term newborns. In our
study, the TC/HDL ratio was higher in both the LBW and high birth weight groups compared with the normal newborn group, while the LDL/HDL ratio was higher in the LBW group compared with the normal weight newborn group. However, there was no significant difference between the high birth weight and normal weight Selleckchem Fluorouracil newborn groups. In addition, there were no significant differences between males and females with regard to the TC/HDL and LDL/HDL atherogenic indices. Since the newborns’ lipid indices could be affected by maternal factors, such as BMI [20], infants whose mothers had a BMI ≤ 25 kg/m2 had higher TC and LDL levels than infants whose mothers had a BMI > 25 kg/m2. Kelishadi et al. demonstrated that mothers with a BMI ≤ 25 kg/m2 before pregnancy had higher cord blood TG and mothers with a BMI > 18 kg/m2 had lower HDL levels [20]. In our study, the roles of both maternal BMI and age were examined, and it was shown that newborns whose mothers were younger than 30 years old and had Cell Cycle inhibitor a BMI > 25 kg/m2 had higher TC and LDL cord blood levels. However, Badiee et al. [21] showed that the cord blood lipid profiles in newborns were not affected by maternal
factors, such as BMI and age. In the study by Nayak et al., they found that maternal BMI had no effect on neonate’s lipid profile [27]. Finally, the sex of newborns does not have any effect on umbilical cord lipids. The TG, TC, LDL, and VLDL levels in LBW and high birth weight newborns were significantly higher than in normal birth weight newborns. TG, TC, LDL, and VLDL levels in LBW and high birth weight newborns were significantly higher than in normal weight newborns. TC and LDL were significantly lower in neonates whose mother’s age ≤ 30 years compared to older mothers. TC and LDL were significantly higher in group whose mother’s BMI ≤ 25 compared to >25. Another prospective study with more sample size is recommended to finding correlation between neonatal birth weight and cord blood lipid profile.