Children with right or severe-to-profound UHL-SN displayed smaller activation in a region encompassing the right inferior temporal, middle temporal, and middle occipital gyrus (BA 19/37/39), evidencing differences due to monaural hearing in cross-modal modulation of the visual processing pathway.
Children with UHL-SN displayed increased activation in the left posterior superior temporal gyrus, likely the result either of more effortful low-level processing of auditory stimuli or differences in cross-modal modulation of the auditory processing pathway. Additionally, children with UHL-SN displayed reduced deactivation of anterior and posterior regions of the default mode network. Results suggest that monaural hearing affects the development of brain networks related to cross-modal sensory processing and the regulation of the default network during processing of spoken language.”
“BackgroundAdherence to controller therapy MI-503 manufacturer in allergic diseases is low. Telemonitoring has been proposed to improve adherence to treatment in chronic diseases. However, this strategy has never been tested in allergic rhinoconjunctivitis. ObjectiveTo test whether Internet-based
telemonitoring during the grass-pollen season of children with allergic rhinoconjunctivitis may enhance adherence to treatment. MethodsChildren and adolescents, 5-18years old, with moderate-to-severe seasonal allergic rhinoconjunctivitis to grass pollen requiring daily administration of nasal corticosteroid (NCS) (mometasone) were recruited (April 2013) in a paediatric allergy practice. Participants were randomized to Internet-based monitoring (AllergyMonitor, AM) or to usual care (no diary at all, controls) and followed from 13 VX-770 Transmembrane Transporters inhibitor May (T0) to 15 June 2013 (T2). An intermediate
visit (T1) check details was performed between 31 May and 2 June. Optimal adherence to therapy was expressed as the use of at least 0.190g/day of mometasone, corresponding to 1puff/nostril/day, and it was measured by canister weights during (T1) and at the end (T2) of the study period. Main secondary outcomes included the reported disease severity (validated self-questionnaire) and quality of life (AdoIRQLQ questionnaire), disease knowledge (multiple-choice questionnaire), nasal flow and resistance at baseline and at T2. ResultsThe use of mometasone, expressed as both optimal adherence rate (48.4% vs. 12.5%; P=0.002) and average daily use (0.200.12g/day vs. 0.15 +/- 0.07g/day; P=0.037), was higher in the AM group (n=31) than among controls (n=32). Disease knowledge improved among the patients using AM (83.3% vs. 68.3%; P smaller than 0.001) but not among controls (68.2% vs. 67.7% right answers; P bigger than 0.05). No differences were observed in the reported severity of disease, nasal flow and resistance and quality of life both at baseline and at follow-up visits. ConclusionsInternet-based telemonitoring improves adherence to NCS treatment and disease knowledge among children and adolescents with seasonal allergic rhinoconjunctivitis.