Deleterious effects of low levels (1-500 mu g/l or 0,004-2 mu M) of methylmercury were only detected with the method to detect chromosomal aberrations. Mitotic index (proportion of cells in metaphase) was the parameter most sensible. Thus, this technique was applied for the analysis of an Amazonian
non-exposed population (Panacauera) with similar social-economical characteristics of the exposed populations studied elsewhere. The mean of the mitotic index for Panacauera population was 0.0814 +/- 0.0097. Inter-individual variability of this index had no relation with sex or age. This value was above those registered for some groups of exposed populations. This fact points to mercury as the main responsible for inhibiting the cell cycle and/or the loss of proliferative capacity of the cells. These results already support mitotic index as an essential https://www.selleckchem.com/products/MLN8237.html parameter for the early diagnose of mercury genotoxicity in humans, and especially in Amazonian populations. (C) 2010 Elsevier Ltd. All rights CYT387 order reserved.”
“Aims Patients with premenstrual dysphoric disorder (PMDD) experience moderate to severe physical and mood symptoms during the luteal phase of their menstrual cycle. The purposes of this study were to examine whether there were significant differences in frontal alpha asymmetry between PMDD and non-PMDD women during a depressive induction condition during the luteal and follicular phases
and to examine the relations between premenstrual distress and depressive symptoms, and frontal alpha asymmetry. Material and Methods The participants included 12 Histone Demethylase inhibitor college women with PMDD and 12 without PMDD as controls. Frontal electroencephalograms (F3/F4) were measured during the luteal and follicular phases of the menstrual cycle in the following sequence: resting baseline, depressive induction, depressive
recall, recovery, and relaxation. Premenstrual distress questionnaires and the Beck Depression Inventory II were administered. Results The participants with PMDD had higher frontal alpha asymmetry than those without PMDD during the depressive induction and relaxation conditions only during the luteal phase. For PMDD and non-PMDD during the luteal phase, a positive correlation was observed between negative affect (measured by premenstrual distress questionnaires) and frontal alpha asymmetry under the depressive induction stage. In addition, higher Beck Depression Inventory II somatic depression was positively correlated with frontal alpha asymmetry under the depressive induction stage. Conclusions This study supports the significant difference between PMDD and non-PMDD on frontal alpha asymmetry, and frontal alpha asymmetry was related to negative affect and somatic depression, while participants with PMDD were in the depressive mood during the luteal phase.”
“Aim The aim of this study was to investigate the associations among depression, anxiety and physical symptoms in peri- and postmenopausal women in a clinical setting.