Filled circles represent a significant change from the 0.05-mg nicotine yield postcigarette measurement, while asterisks (*) … Visual selleckchem Rapamycin Analog Scale. Nicotine effects on VAS stimulated varied as a function of sensation-seeking status (Figure 2, Panel B). Simple effects indicated that increases in ratings occurred as a function of nicotine yield in low sensation seekers alone, while high sensation seekers reported higher ratings of stimulated than low sensation seekers after smoking the 0.05-mg cigarette (p = .07). These results were similar to those on MNWS restlessness, with changes in ratings among high sensation seekers dependent on smoking but independent of nicotine yield, and changes among low sensation seekers dependent on nicotine yield.
Nicotine effects on other VAS items did not differ as a function of sensation-seeking status. Panel B of Figure 3 presents the pooled effects of nicotine yield on ratings of anxious. Significant effects of nicotine yield were found, with follow-up testing indicating reductions in deprivation-induced ratings of anxious at 0.6- and 0.9-mg yields relative to 0.05 mg. Panel C of Figure 3 presents a main effect of nicotine yield on ratings of light headed. Follow-up testing indicated increases in ratings of light-headed at the 0.6- and 0.9-mg yields relative to 0.05 mg. Similar effects were found on ratings of head rush (Figure 3, Panel D), stimulated, like drug, pleasant feeling, and sedated. Profile of Mood States. Nicotine effects on POMS elation varied as a function of sensation-seeking status (Figure 2, Panel C).
Simple effects indicated nicotine-induced increases in both low and high sensation seekers, with a larger magnitude increase observed in low sensation seekers. In addition, high sensation seekers reported higher ratings of elation than low sensation seekers after smoking the 0.05-mg cigarette (p = .07). While group differences were found on ratings of vigor, with high sensation seekers reporting higher ratings than low sensation seekers, no main effects of nicotine yield or nicotine yield by group interactions were observed. Nicotine effects on other POMS scales did not differ as a function of sensation-seeking status. Figure 3 (Panel E) presents the pooled ratings of total positive. A main effect of nicotine yield was observed, with ratings at the 0.9-mg nicotine yield significantly increased compared with the 0.
05-mg yield. Similar effects were observed on ratings of friendliness. Nicotine yield-dependent decreases were observed on ratings Brefeldin_A of anxiety, anger, and depression. Addiction Research Center Inventory. The effects of nicotine yield on the PCAG Scale varied as a function of sensation-seeking status, with simple effects indicating a nicotine-yield dependent decrease among high sensation seekers only. In addition, high sensation seekers reported lower PCAG scores for both the 0.05- and 0.9-mg nicotine yields compared with low sensation seekers.