For perforated giant duodenal ulcers, the defect is often too large to perform a primary repair. Leak rates of up to 12% have been reported from attempted closure with an omental patch procedure [74]. The proximity of the defect and its relation to the common bile duct and ampulla of Vater must also be thoroughly investigated. Intraoperative cholangiography may even be necessary to verify
common bile duct anatomy. There are several different procedures that have been described for duodenal defects such as a jejunal serosal patch, tube duodenostomy, and several variations of omental plugs antrectomy with diversion is the classic and most commonly described intervention, if the Erastin mouse ampullary region is not involved. Affected patients are often in extremis at the time of presentation, and therefore a damage control procedure will likely be the safest and most appropriate see more operation
for the patient. An antrectomy, with resection of the duodenal defect for duodenal ulcers proximal to the ampulla, will allow a definitive control of the spillage. Depending upon the location of the duodenal defect, closure and diversion via antrectomy may be the safest method for damage control. The proximal gastric remnant should be decompressed with a nasogastric tube placed intraoperatively with verification of its correct position. Anastomoses should be GANT61 chemical structure avoided in presence of hypotension or hemodynamic instability, especially if the patient requires vasopressors. After copious abdominal irrigation, a temporary abdominal closure device can be placed. The patient can then be resuscitated appropriately in the ICU. The surgeon can return to the OR for re-exploration, restoration of continuity, possible vagotomy, and closure of the abdomen once the patient is hemodynamically stable [75]. We suggest resectional surgery in case of perforated peptic ulcer larger than 2 cm (Additional file 4 : Video 4) We suggest resectional surgery in presence of malignant perforated ulcers or high risk of malignancy
(e.g. large ulcers, endoscopic features of malignancy, presence of secondary lesions or suspected metastases, etc.) (Additional Epothilone B (EPO906, Patupilone) file 4 : Video 4). We suggest resectional surgery in presence of concomitant significant bleeding or stricture. We suggest use of techniques such as jejunal serosal patch or Roux en-Y duodenojejunostomy or pyloric exclusion to protect the duodenal suture line, in case of large post-bulbar duodenal defects not amenable to resection (i.e. close to or below the ampulla). Whenever possible (i.e. stable patient), in case of repair of large duodenal ulcer, we suggest to perform a cholecistectomy for external bile drainage (e.g. via trans-cystic tube). We suggest duodenostomy (e.g.