Given that gaze cues impart critical information regarding others’ feelings and intentions, it is not surprising that abnormalities in gaze processing are prevalent among individuals with autism, who display severe impairments in social functioning and understanding. Reduced attention to faces, and Epigenetic Reader Domain inhibitor specifically the eyes, in the first year of life is associated with the development of autism (Osterling et al. 2002). Toddlers who develop autism often show profoundly delayed gaze following and joint attention, which has been found to predict subsequent language delays (Sigman et al. 1986; Mundy et al. 1987). Reduced or poorly modulated

eye contact typically Inhibitors,research,lifescience,medical continues into childhood and beyond. When adults with autism do attend to faces, they have been found to fixate less on the eyes, unless explicitly instructed to do so (Pelphrey et al. 2002). Such abnormalities may also underlie characteristic impairments in recognizing Inhibitors,research,lifescience,medical and interpreting emotions, which are disproportionately conveyed by the eyes. Work on gaze fixation behavior Inhibitors,research,lifescience,medical of babies with autism has been difficult to attain, but one study found that when cued to pay attention to the eyes, 2-year olds with autism will orient their attention in response to averted gazes (Chawarska et al. 2003). However, unlike typically developing (TD) toddlers who show enhanced response

to facial gaze direction, toddlers with autism respond equally well to directional, nonsocial symbols. Inhibitors,research,lifescience,medical Why eye cues appear not to be as salient for individuals with autism, and how this relates to the abnormal development of other neural systems in childhood, is largely unknown. Neuroimaging studies have recently begun to address this issue showing, for example, that brain regions

critical to processing shifts in gaze Inhibitors,research,lifescience,medical are insensitive to violations of contextual cues in adult individuals with autism spectrum disorders (ASD; Pelphrey et al. 2005) as well as a lack of activity in fronto-parietal attentional networks in response to gaze cues in children with ASD (Greene et al. in press). Gaze processing abnormalities may be present early in development, and may underlie specific social deficits aminophylline that emerge in autism, but the precise ways in which this might occur has incited great debate. The failure of children with autism to engage in normal, direct eye contact has led to the formulation of a “gaze aversion hypothesis” whereby these children are hypothesized to avoid mutual eye gaze because it is aversive or overly arousing to them, and some neuroimaging studies have highlighted neural mechanisms that may be involved (e.g., Dalton et al. 2005; see Bowman et al. 2004 for a discussion). Alternatively, children with ASD may engage in reduced mutual eye contact or gaze monitoring because it may be intrinsically less interesting to them, and/or may not carry the same informational value as for TD children.