Gut 2012, 61:43–52.PubMedCrossRef 18. Yan GR, Xu SH, Tan ZL, Yin XF, He QY: Proteomics characterization of gastrokine https://www.selleckchem.com/products/10058-f4.html 1-induced growth inhibition of gastric cancer cells. Proteomics 2011, 11:3657–3664.PubMedCrossRef 19. Toback FG, Walsh-Reitz MM, Musch MW, Chang

EB, Del Valle J, Ren H, Huang E, Martin TE: Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am J Physiol Gastrointest Liver Physiol 2003, 285:G344-G353.PubMed 20. Moss SF, Lee JW, Sabo E, Rubin AK, Rommel J, Westley BR, May FE, Gao J, Meitner PA, Tavares R, Resnick MB: Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis. Clin Cancer Res 2008, 14:4161–4167.PubMedCrossRef 21. Vogler M: BCL2A1: the underdog in the BCL2 family. Cell Death Differ 2012, 19:67–74.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions Mao W and Chen J performed the experiments and wrote the paper;

Peng TL and Yin XF organized the figures and collected tissue specimens and patients’ data; Chen MH designed this study and supervised the writing and discussion. All authors SIS3 purchase have read and approved the final version of this manuscript.”
“Introduction Burkitt lymphoma is a high-grade, rapidly-growing and aggressive

B-cell non-Hodgkin’s lymphoma [1]. Three forms are recognized: http://www.selleck.co.jp/products/E7080.html those endemic to Africa, sporadic forms, and those associated with immunodeficiency states. In the endemic and sporadic forms, B lymphocytes possess rearranged immunoglobulin genes and most commonly carry the (8;14) chromosomal translocation of the proto-oncogene c-myc[1]. Although Burkitt lymphoma is sensitive to chemotherapy, the different regimens used to treat this cancer are associated with varied success rates [1, 2]. Prognosis depends on the stage of the disease at diagnosis and is generally worse for children, adolescents, and patients with co-existent AIDS. Baicalin is one of several pharmacologically-active flavones present in Scutellaria baicalensis Georgi (Huang-qin or Chinese skullcap), a plant widely used in traditional Chinese herbal medicine [3]. Although baicalin is generally non-toxic to normal tissues, it exhibits strong anti-inflammatory, anti-viral, and anti-tumor activities [4, 5]. Growth of human leukemia and myeloma cells and of human hepatic, see more prostate, breast, lung, bladder, and estrogenic cancer cells is potently suppressed by this flavone. Molecular mechanisms underlying these growth-suppressive effects are thought to include changes in oxidation/reduction status, cell cycle inhibition, and induction of apoptosis [3–5].