In recent years integration of the dopamine and glutamate signaling GNS-1480 pathways has received increasing attention. This research has been fueled by the fact that many psychiatric conditions, including schizophrenia, seem to be due to imbalances in both the glutamatergic and the dopaminergic system, and that many addictive drugs seem to affect both systems. Thus more knowledge about the interaction between the glutamatergic and dopaminergic systems will have important implications for the generation of new treatment for psychiatric disorders. This review will focus on the intra-neuronal interaction between the glutamate and dopamine
systems. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Background Although life expectancy in the European Union
(EU) is increasing, whether most of these extra years are spent in good health is unclear. This information would be crucial to both contain health-care costs and increase labour-force participation for older people. We investigated inequalities in life expectancies and healthy life years (HLYs) at 50 years of age for the 25 countries in the EU in 2005 and the potential for increasing the proportion of older people in the labour force.
Methods We calculated life expectancies and HLYs at 50 years of age by sex and country by the Sullivan method, which was applied to Eurostat life tables and age-specific prevalence of activity limitation from find more the 2005 statistics of living and income conditions survey. We investigated
differences between countries through meta-regression Resveratrol techniques, with structural and sustainable indicators for every country.
Findings In 2005, an average 50-year-old man in the 25 EU countries could expect to live until 67.3 years free of activity limitation, and a woman to 68.1 years. HLYs at 50 years for both men and women varied more between countries than did life expectancy (HLY range for men: from 9.1 years in Estonia to 23.6 years in Denmark; for women: from 10 . 4 years in Estonia to 24. 1 years in Denmark). Gross domestic product and expenditure on elderly care were both positively associated with HLYs at 50 years in men and women (p<0 . 039 for both indicators and sexes); however, in men alone, long-term unemployment was negatively associated (p=0 . 023) and life-long learning positively associated (p=0 . 021) with HLYs at 50 years of age.
Interpretation Substantial inequalities in HLYs at 50 years exist within EU countries. Our findings suggest that, without major improvements in population health, the target of increasing participation of older people into the labour force will be difficult to meet in all 25 EU countries.
Funding EU Public Health Programme.”
“The glutamate receptor delta 2 (GluR delta 2) subunit has been classified as an ionotropic glutamate receptor on the basis of the amino acid sequence. It is considered an orphan receptor since no physiological ligand has so far been identified.