Moreover, an acute reload of atorvastatin even in the context of

Moreover, an acute reload of atorvastatin even in the context of chronic statin has been associated with a significant reduction within 30 days of major adverse cardiac events after percutaneous coronary intervention. Patients on statins at the time of percutaneous coronary intervention also had a lower incidence of contrast-induced nephropathy,

as compared with those that were statin-naive. Finally, atorvastatin pretreatment may prevent the occurrence of atrial fibrillation in patients undergoing elective cardiac surgery. Overall, this evidence may strongly influence the clinical practice of interventional cardiologists and cardiac surgeons.”
“Helium bubbles form in metal tritide films as tritium decays into He-3, influencing mechanical properties and long-term film stability. The bubble nucleation and growth mechanisms comprise an active

research area, but there has been only one previous systematic experimental study of helium bubble growth in metal tritides, on zirconium tritides. There have been no such studies on tritides such as ErT2 that form platelike bubbles and lack a secondary bubble population on a network of line dislocations, Blebbistatin and yet such a study is needed to inform the modeling of helium bubble microstructure development in a broader range of metal tritides. Transmission electron microscopy has been used to study the growth and evolution of helium bubbles in ErT2 films over a four-year period. The results Selleckchem Nepicastat have been used

to test the present models of helium bubble nucleation and growth in metal tritides, particularly those forming platelike bubbles. The results support the models of Trinkaus and Cowgill. The observations of nonuniform bubble thicknesses and the pattern of grain-boundary bubble formation, however, indicate that these models could be strengthened by closer attention to details of interfacial energy. It is strongly recommended that efforts be made (either experimentally or by calculation) to determine anisotropy of tritide/helium interfacial energy, both for clean, stoichiometric interfaces, and also allowing for such factors as nonstoichiometry and segregation. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3359653]“
“Simultaneous heart-kidney transplantation (SHK) remains uncommon in the US. We examined outcomes of SHK compared to heart transplant alone (HTA) and deceased donor kidney transplant (DDKT).

Data from OPTN/UNOS heart and kidney data bases were used to identify 16 710 HTA, 263 SHK transplants and 68 833 DDK transplants between 1998 and 2007. Outcomes included patient survival (PS), acute cardiac and renal rejection and renal graft survival (rGS).

The adjusted risk of death was 44% lower with SHK compared to HTA. Over half of SHK were performed in cases where pretransplant dialysis was not initiated.

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