Mutations in the hemochromatosis (HFE) gene, detected using PCR-RFLP, were found in 30.4% of these beta-thalassemic patients; heterozygosity for H63D (20.3%) was the most frequent. Ferritin levels and transferrin saturation were similar in beta-thalassemics with and without mutations in the HFE gene. Ferritin concentrations were significantly higher in men and in individuals over 40 years of age. Transferrin saturation also was significantly higher in men, but only in those without
HFE gene mutations. There was no significant difference in the iron profile among the beta(0) and beta(+) thalassemics, with and without HFE gene mutations. The frequency of ferritin values above 200 ng/mL in women and 300 ng/mL LY3039478 in men was also similar in beta 0 and beta+ thalassemics (P > 0.72). Our conclusion is that ferritin levels are variable in the beta-thalassemia, trait regardless of the type of beta-globin mutation. Furthermore, HFE gene polymorphisms do not change the iron profile in these individuals.”
“There is concern that research reimbursements to adolescents may increase substance use However these concerns have not been examined empirically Participants
were 70 adolescents (13-19 years) with at least one non-nicotine substance use disorder (SUD) enrolled in a 12-week clinical trial of atomoxetine/placebo for attention/deficit-hyperactivity disorder (ADHD) Adolescent participants received cash reimbursement after each study visit (maximum possible=$425 HSP inhibitor Alisertib supplier over 12 weeks) Participants reported each week how they spent the previous reimbursement Results were tallied and correlates of spending a payment on substances
were examined Results showed that 26 of 70 subjects reported spending at least one research payment on alcohol or drugs and 25 of 70 subjects reported spending at least one payment on tobacco Comparing those who did and did not spend a research payment on alcohol/drugs those who did had more frequent baseline alcohol/drug use but did not differ in demographics (age gender) or other clinical characteristics (ADHD severity diagnosis of conduct disorder number of SUD diagnoses number of treatment sessions attended or pre/post-change in number of days used substances in the past 28 days) Comparing those who did and did not spend a payment on tobacco those who did were slightly older and had more frequent baseline tobacco use In conclusion a significant proportion of subjects used at least a portion of one research payment to buy alcohol drugs or tobacco However there was little indication that research payments increased substance use (C) 2010 Elsevier Ireland Ltd All rights reserved”
“Extracts of Phyllanthus niruri L., collected from three different areas in the Congo (Kisantu, Kimwenza and University of Kinshasa), used for malaria treatment were tested in vitro in order to evaluate their antiplasmodial properties.