Our present study demonstrates continued prevalence of G1, G2, G9 and G12 G-genotypes along with P[4], P[6] and P[8] P-genotypes in Delhi during 2007–2012. G1P[8], G2P[4], G9P[8] and G12P[6] were the most common strains detected during the entire study period. Nearly similar VX-809 rotavirus strain distribution at AIIMS and KSCH hospitals suggests that the genotyping

data obtained during the decade long surveillance at AIIMS accurately represents rotavirus distribution across the entire city. Compared with our previous study, we observed G9P[4] rotavirus at a relatively higher percentage indicating their possible emergence. Finally, in view of ROTAVAC vaccine licensing in India, the genotyping data obtained during continued surveillance in Delhi could serve as a background for estimating vaccine effectiveness. We have now expanded our surveillance studies beyond Delhi to other cities in Northern India to ascertain overall rotavirus diversity in the entire northern part of India. None. We acknowledge the Indian Council of Medical Research (ICMR), Government of India for providing financial support (Grant no.5/8-1-217/D/2007/ECD-II) to carry out this work. Senior Research Fellowship from ICMR to V.R.T. and Research Associateship to S.S. from Council for

Scientific and Industrial Research (CSIR) is also acknowledged. “
“Group-A Rotaviruses (RV) are the most Compound Library important etiologic agents of acute gastroenteritis in infants and young children, worldwide. Globally, group-A RV infections account for 37% of all cases of diarrhoea and 4,53,000 deaths per year in children under the age of 5 years [1]. RV has been less appreciated as a pathogen of adults, although cases of rotavirus gastroenteritis have been identified in elderly and immunocompromised individuals [2], [3] and [4]. In healthy adults, infection usually causes few or mild symptoms. However, in immunocompromised patients, infection

can be severe and persistent, with patients presenting with vomiting, malaise, abdominal pain, diarrhoea and fever [2]. RVs belong to the family Reoviridae, and are classified in eight antigenic groups (A–H), of which, groups A, B and C are known to infect humans. The virus carries a genome of 11 segments of double-stranded RNA (dsRNA) encoding six structural (VP1–VP4, VP6 and VP7) and six non-structural (NSP1–NSP6) proteins. The two Metalloexopeptidase outer-layer proteins VP7 and VP4 form the basis of the current dual classification system of RVA into G and P genotypes [5]. To date, at least 27 G (G1–G27) and 37 P (P[1]–P[37]) genotypes of group-A RV have been identified globally, with various combinations of G and P genotypes [6], [7] and [8]. However, only the five most common types (G1–G4, P[8]) have been targeted in the RV vaccines. In order to assess the impact of vaccines on circulation of wild type strains, long-term surveillance for group-A RV infections and strains have been conducted in several countries [9], [10] and [11].