Results: The 3 varicella vaccines in China (Varilrix from GlaxoSmithKline, Changchun and Shanghai from Changchun and Shanghai Institutes

of Biologic Products, respectively) had similar effectiveness: Varilrix 86.4% (95% confidence interval [CI] : 72.6, 93.2), Changchun 79.5% (95% CI: 58.1, 90.0), and Shanghai 92.6% (95% CI: 68.9, 98.2). Vaccine effectiveness was higher during the first year after vaccination than during the subsequent 5 years, but the differences did not reach statistical significance.

Conclusions: The varicella vaccines in China are highly effective in preventing THZ1 concentration clinical varicella. Further studies on laboratory-confirmed cases are needed to verify the change of vaccine-induced immunity over time.”
“In this study, L1(1) CoPt (111) films were deposited on glass substrates at 300 degrees C with observed superlattice (111) and (333) peaks and Galardin ic50 easy axis distribution of 2 degrees. The magnetic anisotropy constant was in the order of 10(7) erg/cm(3). The effect of CoPt layer thickness on domain structure and magnetic properties was investigated. With increasing

film thickness, the squareness was reduced and the nucleation field changed from negative to positive, indicating low impedance to domain wall motion and increased demagnetizing energy. Magnetic force microscopy images demonstrated the magnetic domain structure changed from irregular and large domains to highly interconnected stripes with increasing CoPt layer thickness. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3561115]“
“Lyme disease (LD) is the most common tick-borne disease in the Northern hemisphere. It is caused by Borrelia burgdorferi sensu lato, in particular, B. burgdorferi sensu stricto, Borrelia

garinii, and Borrelia afzelii. However, other Stattic genospecies have been implicated as causative factors of LD as well. Borrelia burgdorferi exhibits numerous immunogenic lipoproteins, but due to strong heterogeneity, the use of these proteins for serodiagnosis and vaccination is hampered. We and others have identified acylated cholesteryl galactosides (ACGal) as a novel glycolipid present in B. burgdorferi sensu stricto, B. afzelii, and B. garinii. ACGal is a strong antigen and the majority of patients display anti-ACGal antibodies in the chronic stages of LD. However, it is unknown whether ACGal is present in other presumably pathogenic B. burgdorferi genospecies. Therefore, we performed an analysis of the total lipid extracts of a wide spectrum of genospecies of B. burgdorferi sensu lato using thin-layer chromatography as well as Western blot and dot-blot assays. We show that ACGal is present in substantial quantities in all B. burgdorferi genospecies tested. Therefore, this molecule might improve the serological detection of rarely pathogenic genospecies, and may be used as a protective vaccine regardless of the prevailing genospecies.