Study Design and Setting: A simulation study was conducted to compare the RD and the ID approaches regarding bias and coverage probability (CP) considering various distributions, baseline risks, effect sizes, and sample sizes. Additionally, the two approaches were compared by using two real data examples.
Results: The
RD approach showed good estimation and coverage properties with only a few exceptions in the case of small sample sizes and small effect sizes. The ID approach showed considerable bias and low CPs in most of the considered data situations.
Conclusions: Absolute risks estimated by means of survival time methods rather than incidence rates should be used to estimate NNTs in RCTs with time-to-event outcomes. (C) 2013 Elsevier Inc. All rights reserved.”
“Objectives: Analyze the Adriamycin cell line anatomical and audiological success rates of myringoplasty in children with craniofacial anomaly, cleft palate and compare them to a control group.
Methods: Retrospective review of medical records for
all children who underwent myringoplasty between 1997 and 2007. The following data was recorded: sex, age, perforation side, size, location and etiology, surgical approach, type of myringoplasty, CA4P research buy graft material, season of surgery, preoperative status of the operated and contralateral ear, history of previous otologic surgery, and adenoidectomy or tonsillectomy.
Results: Myringoplasty outcomes of 22 craniofacial anomaly patients (15/22 were cleft palate patients) were compared to 144 controls. Children in the craniofacial anomaly group demonstrated a tendency towards surgery at
an older age. Children in the craniofacial anomaly and cleft palate groups had a significant positive history of previous otologic procedures to both operated and contralateral ears. Peroperative subannular ventilation T-tubes were more frequently recorded in patients with craniofacial anomaly than patients in the control group. The craniofacial anomaly, cleft palate and control group had comparable mean preoperative and postoperative ABG and their ABG improvement was statistically significant. Children with CDK activity craniofacial anomaly, cleft palate and control group shared similar anatomical and audiological success rates (ABG <20 dB) at 6, 12 and 24 months.
Conclusions: Although children in the craniofacial anomaly and cleft palate groups are predisposed to middle ear disease, their disease responds well to surgical intervention. Their audiological and anatomical success rates were equivalent to the ones observed in the control group. In light of our results, we recommend that myringoplasty in children with craniofacial anomaly and cleft palate be performed after the age of 12. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Objective: The aim of the present study was to evaluate the bioequivalence of two oral clopidogrel (CAS 113665-84-2) formulations.
Method.