The aim of this study was to investigate the effect of salbutamol on D-L,CO in subjects with and without airway obstruction and reversibility.
MethodsSixty subjects were investigated with 20 in each of the three groups: normal spirometry; irreversible obstruction; and reversible
obstruction. Baseline spirometry, plethysmographic lung volumes, D-L,CO, pulse rate and arterial blood gases were measured. The same testing sequence was repeated after administration of a placebo inhaler and again after 400g salbutamol.
ResultsSalbutamol did not affect the mean alveolar volume (V-A) (P>0.05), transfer coefficient for carbon monoxide (D-L,CO/V-A, KCO) (P>0.05) or D-L,CO (P>0.05) in the normal and irreversible obstruction groups. In Savolitinib purchase the reversible obstruction group, salbutamol caused an increase in the mean V-A compared with placebo (P<0.001). However, the mean KCO was reduced (P<0.001). The mean change in D-L,CO was not significant (P>0.05). A considerable Rapamycin clinical trial reduction in D-L,CO was found after salbutamol in four subjects in the reversible group as a result of a minor
increase in V-A and substantial decrease in KCO. No statistical difference in pulse rate or arterial blood gases values was detected.
ConclusionsSalbutamol had no effect on the mean D-L,CO in any group. However, salbutamol may considerably reduce D-L,CO in some individuals with reversibility secondary to its effects on V-A and KCO.”
“Background and aims: Animal contact may reduce the risk
not only for allergic diseases but also for inflammatory bowel diseases (IBD). Selleck Copanlisib We aimed to clarify the association between endotoxin levels in the home environment and IBD.
Methods: A case control study including 85 IBD cases (aged: 8-29 years) and 91 controls undergoing strabismus surgery (aged: 11-23 years) was conducted in Southern Germany. A questionnaire and a dust sampling sock were mailed to the parents (Response: 71% among cases, 58% among controls). Endotoxin levels were determined using Limulus Amoebocyte Lysate assay tests. Logistic regression models adjusting for age, sex, high parental school education, family history of IBD, environmental factors in the first year of life (urban place of living, farm animal or pet contact), and presence of cats or dogs in the room were performed.
Results: Geometric mean levels of endotoxin were lower among cases (50.67 Endotoxin Units (EU)/mg; geometric standard deviation (GSD); 2.32) than controls (60.25 EU/mg; GSD: 2.22). Endotoxin levels were inversely, but not statistically significantly, related to case status in the multivariate logistic regression analysis (OR for the interquartile range increase: 0.70; 95%CI: 0.46-1.04).
Conclusion: In our study sample, high endotoxin levels were inversely related to case status.