These findings indicate that p14ARF has an extra action in tumor suppression, independent of p53 via the negative regulation of angiogenesis. This exercise is mediated by TIMP3 induction, emphasizing the importance of both p14ARF and regulators of extracellular matrix remodeling in suppression of angiogenesis. AN 09. IDENTIFICATION OF ENDOTHELIAL PROGENITOR CELLS IN HUMAN GLIOMA AND BLOOD SAMPLES AS INDICATOR FOR GLIOMA NEOANGIOGENIC Exercise Ping Pin Zheng,1 Marcel van der Weiden,one Martin J. van den Bent,two Peter A. E. Sillevis Smitt,two Theodorus M. Luider,two and Johan M. Kros1, Departments of 1Pathology and 2Neurology, Erasmus Health care Center, Rotterdam, The Netherlands Neovascularization is essential for tumor development and invasion. Most endothelial progenitor cells reside in bone marrow and therefore are mobilized and enter the circulation by cytokines or angiogenic development factors triggered by diverse physiological or pathologi cal stimuli.
In experimental designs, it’s been shown that EPCs enter the interstitial area wherever they encourage de novo vessel formation by integrat ing into vessels or consider part inside the formation of completely new vessels. Regardless of whether this scenario really takes place in sufferers with glial tumors is unknown. Thus far, the recruitment of description EPCs and their incorporation into tumor tissues has become investigated only in animal models and in ex vivo experiments with exogenously transported EPCs. Within this research, we investigated the presence of activated kinase inhibitor DZNeP EPCs in biopsy specimens and periph eral blood samples of patients with glial tumors. The EPCs have been found predominantly as solitarily deposited cells and cell chains through the entire tumors or as constituents of hyperplastic vessels. We had been able to identify enhanced numbers of circulating EPCs in blood samples taken preopera tively from the glioma patients.
We matched the percentages of those EPCs with people present inside the tissue samples from the tumors by double and triple

labeling experiments. The findings provide evidence that EPCs contribute to glioma neovascularization in vivo. The presence on the EPC population may become a diagnostic parameter for glioma progression or serve as a potential target for antiangiogenic therapy. AN 10. ELEVATED EXPRESSION OF VASCULAR ENDOTHELIAL Development FACTOR CORRELATES WITH Greater ANGIOGENESIS AND DECREASED PROGRESSION FREE SURVIVAL IN NEUROENDOCRINE TUMOR James C. Yao,1 Jun Zhang,1 Zhiliang Jia,1 and Keping Xie1,2, Departments of 1Gastrointestinal Medical Oncology and 2Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA Vascular endothelial development factor is a critical proangiogenic factor in almost all solid tumors.