They further reported that silencing of NDRG2 attenuates p53-mediated apoptosis. These

data strongly suggested that NDRG2 was an important factor in regulating tumor cell apoptosis. Conclusions Our results show that enforced NDRG2 expression significantly inhibited RCC cell growth, and induced eFT-508 order apoptosis in human renal carcinoma cells. We also observed that NDRG2 expression could be upregulated by p53 in dose dependent manner. Further research may help design an effective therapeutic modality to control renal cancer. Acknowledgements The Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China (Program No. 2009JM4003-3) References 1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ: Cancer statistics, 2007. CA Cancer J Clin 2007, Selleckchem SC79 57:43–66.PubMedCrossRef 2. Boulkroun S, Fay M, Zennaro MC, Escoubet B, Jaisser F, Blot-Chabaud M, Farman N, Courtois-Coutry N: Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. J Biol Chem 2002, 277:31506–31515.PubMedCrossRef 3. Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F, Ji S, et al.: N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Int J Cancer 2003, 106:342–347.PubMedCrossRef 4. Qu X, Zhai Y, Wei H, Zhang C, Xing G, Yu Y, He F: Characterization and expression

of three click here novel differentiation-related genes belong to the human NDRG gene family. Mol Cell Biochem 2002, 229:35–44.PubMedCrossRef 5. Mitchelmore C, Buchmann-Moller S, Rask L, West MJ, Troncoso JC, www.selleck.co.jp/products/forskolin.html Jensen NA: NDRG2: a novel Alzheimer’s disease associated protein. Neurobiol Dis 2004, 16:48–58.PubMedCrossRef 6. Choi SC, Kim KD, Kim JT, Kim JW, Yoon DY, Choe YK, Chang YS, Paik SG, Lim JS: Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. FEBS Lett 2003, 553:413–418.PubMedCrossRef 7. Hummerich L, Muller R, Hess J, Kokocinski F, Hahn M, Furstenberger G, Mauch C, Lichter P, Angel P: Identification

of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development. Oncogene 2006, 25:111–121.PubMed 8. Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A: Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Cancer Res 2005, 65:7121–7126.PubMedCrossRef 9. Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, Misra A, Nigro JM, Colman H, Soroceanu L, et al.: Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006, 9:157–173.PubMedCrossRef 10. Ma J, Jin H, Wang H, Yuan J, Bao T, Jiang X, Zhang W, Zhao H, Yao L: Expression of NDRG2 in clear cell renal cell carcinoma. Biol Pharm Bull 2008, 31:1316–1320.PubMedCrossRef 11.