: Study on the expression and clinical significances of Lewis y antigen and

BKM120 ic50 integrin αv, β3 in epithelial ovarian tumors. Int J Mol Sci 2011, 12:3409–3421.PubMedCrossRef 7. Taylor ST, Hickman JA, Dive C: Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors. J Natl Cancer Inst 2000, 92:18–23.PubMedCrossRef 8. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al.: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943–1947.PubMedCrossRef 9. Steck PA, Perhouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, et al.: Identification of a candidate ATM/ATR cancer tumour suppressor gene, MMAC1, at chromosome 10q23. 3 that is mutated in multiple advanced cancer. Nat Genet 1997, 15:356–362.PubMedCrossRef 10. Damiano JS, Cress AE, Hazlehurst LA, Shtil AA, Dalton WS: Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 1999, 93:1658–1667.PubMed 11. Zhang F, Liu J, Lin B, Liu Q, Zhao Y, Zhu L, et al.: Increase in docetaxel-resistance of ovarian carcinoma-derived RMG-1 cells with enhanced expression of Lewis Y antigen. Int J Mol Sci 2011, 12:7323–7334.PubMedCrossRef 12. Iwamori M, Tanaka K, Kubushiro K, Lin B, Kiquchi K, Ishiwata I, et al.: Alterations

in the glycolipid composition and cellular properties of ovarian carcinoma-derived RMG-1 cells on transfection of the α1,2-fucosyltransferase gene. Cancer Sci selleck inhibitor Thymidine kinase 2005,96(1):26–30.PubMedCrossRef 13. Easton EW, Bolsche JG, van den Eijnden DH: Enzymatic amplification involving glycosyltransferases forms the basis for the increased size of asparagine-linked glycans at the surface of NIH 3 T3 cells expressing the

N-ras proto-oncogene. J Boil Chem 1991, 266:21674–21680. 14. Zhao Y, Itoh S, Wang X, Miyoshi E, Kariya Y, Miyazaki K, et al.: Deletion of core fucosylation on α 3 β 1 integrin down-regulates its functions. J Boil Chem 2006,281(50):38343–38350.CrossRef 15. Yan LM, Lin B, Zhu LC, Hao YY, Qi Y, Wang CZ, et al.: Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin a5β1with the LewisY-structure on transfection of the a1, 2-fucosyltransferase gene. Biochimie 2010, 92:852–857.PubMedCrossRef 16. Li Q, Liu S, Lin B, Yan L, Wang Y, Wang C, et al.: Expression and Correlation of Lewis y Antigen and Integrins a5 and β1 in Ovarian Serous and Mucinous Carcinoma. Int J Gynecol Cancer 2010, 20:1482–1489.PubMed 17. Wang C, Yan L, Wang Y, Lin B, Liu S, Li Q, et al.: Overexpression of Lewis (y) antigen protects ovarian cancer RMG-1 cells from carboplatin-induced apoptosis by the Upregulation of Topo-I and Topo-II b. The anatomical record 2011, 294:961–969.PubMedCrossRef 18. Maubant S, Cruet-Hennequart S, Poulain L, Carreiras F, Sichel F, Luis J, et al.