When activation of the catheterization laboratory is considered appropriate, the on-call interventionalist contacts a central number to mobilize the catheterization laboratory team, and the patient is transferred to the catheterization laboratory. Because the system does not allow for pre-activation of the catheterization laboratory team from the ambulance, none of the patients bypassed the ED en-route to the catheterization laboratory. The term ‘self-transport’ refers to patients who arrive at the ED using transportation

that did not involve EMS. These modes of transportation include public transportation, taxi, self-driven or driven by others, or walked to the hospital. These patients may have also visited another healthcare facility after symptom onset, before arriving at the ED by non-EMS transport. They also go through the usual triaging process in the ED. Following a diagnosis of STEMI on ECG, the interventionalist OSI-906 nmr and the catheterization laboratory team are mobilized in SB203580 the usual manner. The following time points were defined and collected contemporaneously for each STEMI patient (Fig. 1): symptom onset time (from patient recall); door time (time of first registered hospital

contact); ECG time (time of inciting STEMI ECG leading to decision to activate the catheterization laboratory); call time (time of call to interventionalist); lab time (time of patient arrival to the cardiac catheterization laboratory); case start time (time of first sheath insertion); and balloon time [time of introduction of first device (balloon catheter, aspiration thrombectomy catheter or stent) restoring antegrade flow]. Time intervals were then calculated from these time points. Door-to-call is to be taken as ED processing time interval, and call-to-balloon is to be taken as laboratory processing time interval. Off-hours presentation was defined as any weekend presentation or weekday presentation from 5 pm to 8 am. ECG criteria defining a STEMI included the presence of at least 1 mm ST-segment elevation in at least Rolziracetam 2 contiguous leads,

or the occurrence of a new left bundle branch block. Angiographic success was defined as a residual stenosis of < 30% with thrombolysis in myocardial infarction grade III flow. The primary end point was DTB time. Secondary end points were the DTB component times, symptom-door and symptom-balloon times. In-hospital outcomes evaluated were death, cardiac death, Q-wave MI, urgent coronary artery bypass graft surgery, and urgent repeat PCI of target lesion. PCI was performed according to guidelines current at the time of the procedure. All patients received an aspirin loading dose of 325 mg, as well as either clopidogrel (600 mg), prasugrel (60 mg) or ticagrelor (180 mg) loading. Anticoagulation regimens were chosen at the operator’s discretion and included unfractionated heparin adjusted to targeted activated clotting time, or bivalirudin 0.