Angiotenzyn – II (AT-II), produced by angiotenzin converting enzyme (ACE), has important role in liver fibrogenesis. Dual antiviral therapy with PEG-IFN and ribavirin beside antiviral effect, leads to the reduction of liver parenchyma fibrosis. Aim: To determine ACE value in serum of

patients with chronic hepatitis C before and after dual antiviral therapy, as well as reduction of liver fibrosis in liver tissue before and after the antiviral selleck chemical treatment Methods: We analysed 50 patients treated at Gastroenterohepatology Department, in the period of four years. Patient were treated with pegylated interferon alfa 2a or 2b and ribavirin with treatment duration depending on genotype. Value of ACE in serum, was determined by Olympus AU 400 device, with application of kit “Infinity TN ACE Liquid Stable Reagent.” HCV RNA levels in sera

were measured by real time PCR. HCV RNA test was performed with Selleck Rucaparib modular analysis AMPLICOR and COBAS AMPLICOR HCV MONITOR test v2.0, which has proved infection and was used for monitoring of the patients respond to the therapy. Liver histology was evaluated in accordance to the level of necroinflammation activity and stadium of fibrosis. Results: Antiviral therapy in chronic hepatitis C statistically decreases serum activities of ACE (p = 0,02) with indirect affects on the fibrogenesis of the liver parenchyma. Among the patients who accepted repeated biopsy after the treatment (35% of total number), 60% had a regression in fibrosis stage. Conclusion: Our results suggested that serum activity of the ACE is valuable indirect parameter of the liver damage, and can be used as a marker of non invasive assessment of intensity of liver damage. Antifibrotic effect of antiviral therapy was also proven by quantification of changes

in liver tissue. Key Word(s): 1. angiotenzin converting enzyme; 2. antiviral therapy; 3. chronic hepatitis C Presenting Author: ILHAMD Additional Authors: ADLIN medchemexpress HERY, MASRUL LUBIS, LUKMAN HAKIM ZAIN Corresponding Author: ILHAMD Affiliations: University of Sumatera Utara, University of Sumatera Utara, University of Sumatera Utara Objective: Over the past 40 years, endoscopy has been used with increasing frequency in the investigation of upper gastrointestinal symptoms. Upper gastrointestinal endoscopy is currently the main diagnostic modality in the work-up of dyspeptic patients. Despite most dyspeptic patient either have no identifiable cause of dyspepsia (non-ulcer dyspepsia, NUD), performing endoscopy in patients with dyspepsia is to detect underlying ulcer disease, gastric cancer or pancreatic disease. The aim of this study was to establish the etiology of dyspeptic symptoms on upper endoscopic investigation.

Angiotenzyn – II (AT-II), produced by angiotenzin converting enzyme (ACE), has important role in liver fibrogenesis. Dual antiviral therapy with PEG-IFN and ribavirin beside antiviral effect, leads to the reduction of liver parenchyma fibrosis. Aim: To determine ACE value in serum of

patients with chronic hepatitis C before and after dual antiviral therapy, as well as reduction of liver fibrosis in liver tissue before and after the antiviral selleck inhibitor treatment Methods: We analysed 50 patients treated at Gastroenterohepatology Department, in the period of four years. Patient were treated with pegylated interferon alfa 2a or 2b and ribavirin with treatment duration depending on genotype. Value of ACE in serum, was determined by Olympus AU 400 device, with application of kit “Infinity TN ACE Liquid Stable Reagent.” HCV RNA levels in sera

were measured by real time PCR. HCV RNA test was performed with GSK2126458 solubility dmso modular analysis AMPLICOR and COBAS AMPLICOR HCV MONITOR test v2.0, which has proved infection and was used for monitoring of the patients respond to the therapy. Liver histology was evaluated in accordance to the level of necroinflammation activity and stadium of fibrosis. Results: Antiviral therapy in chronic hepatitis C statistically decreases serum activities of ACE (p = 0,02) with indirect affects on the fibrogenesis of the liver parenchyma. Among the patients who accepted repeated biopsy after the treatment (35% of total number), 60% had a regression in fibrosis stage. Conclusion: Our results suggested that serum activity of the ACE is valuable indirect parameter of the liver damage, and can be used as a marker of non invasive assessment of intensity of liver damage. Antifibrotic effect of antiviral therapy was also proven by quantification of changes

in liver tissue. Key Word(s): 1. angiotenzin converting enzyme; 2. antiviral therapy; 3. chronic hepatitis C Presenting Author: ILHAMD Additional Authors: ADLIN MCE公司 HERY, MASRUL LUBIS, LUKMAN HAKIM ZAIN Corresponding Author: ILHAMD Affiliations: University of Sumatera Utara, University of Sumatera Utara, University of Sumatera Utara Objective: Over the past 40 years, endoscopy has been used with increasing frequency in the investigation of upper gastrointestinal symptoms. Upper gastrointestinal endoscopy is currently the main diagnostic modality in the work-up of dyspeptic patients. Despite most dyspeptic patient either have no identifiable cause of dyspepsia (non-ulcer dyspepsia, NUD), performing endoscopy in patients with dyspepsia is to detect underlying ulcer disease, gastric cancer or pancreatic disease. The aim of this study was to establish the etiology of dyspeptic symptoms on upper endoscopic investigation.

04, P=0.553), beta-trace protein (β=−0.10, P=0.173) and beta-2 microglobulin (β=−0.30, P=0.344) selleck levels. Models that included Cr, cystatin C, age and gender (Model 1) and Cr, cystatin C, beta-2 microglobulin, age and gender (Model 2) resulted

in the best fit to predict mGFR. Among 59 subjects with cirrhosis and ascites, the accuracy of Models 1 and 2 was significantly superior to conventional GFR-estimating equations (Table 1). Conclusions: Alternative renal function biomarkers, cystatin C, beta-2 microglobulin and beta-trace protein were not dependent on gender in patients with cirrhosis; whereas gender influenced serum Cr independent of mGFR. Models developed from subjects with cirrhosis that included serum Cr, cystatin C and beta-2 microglobulin

were more accurate predictors of mGFR than CrCl, eCrCl and conventional GFR equations among patients with ascites. Disclosures: Ayse L. Mindikoglu – Grant/Research Support: NIH/NIDD K5 K23 DK089008-04, Living Legacy Foundation of Maryland Charles Howell – Advisory Committees or Review Panels: Janssen, Inc,, Abb-Vie; Grant/Research Support: Gilead Sciences, Bristol Myer Squibb, Boehringer Ingelheim The following people have nothing to disclose: Thomas C. Dowling, Laurence S. Magder, Robert H. Christenson, Matthew R. Weir, Stephen L. Seliger, William R. Hutson Objectives: Cirrhosis of the liver is a disease that occurs worldwide. Current guidelines for clinical practice recommend the infusion of human albumin after large volume paracentesis. After inspecting the actual evidence behind this Selleck H 89 recommendation, we decided to conduct a systematic review and meta-analysis to address whether or not, albumin infusion has an effect on mortality and morbidity in the context of large volume paracentesis. Methods: We performed a comprehensive search of large databases and abstract books of conference proceedings up to Dec. 31st 2013. We were finally able to include 21 randomized controlled trials, testing the infusion of human albumin against alternatives (vs. no treatment, vs. plasma expanders; vs.

vasoconstrictors) in HCC-free patients suffering from cirrhosis, totaling 1108 patients. We then analyzed them with regard to mortality, changes in plasma 上海皓元医药股份有限公司 renin activity (PRA), hyponatremia, renal impairment, recurrence of ascites with consequential re-admission into hospital and “additional complications” (bleeding from esophageal varices, infections, sepsis and multiple-organ dysfunction-syndrome). Additionally, we employed trial sequential analysis in order to calculate the number of patients required in controlled trials in order to be able to determine a statistically significant advantage of the administration of one agent over another with regard to mortality. Results: While the administration of albumin effectively prevents a rise in PRA as well as hyponatremia, strong clinical endpoints, especially mortality are not significantly improved.

04, P=0.553), beta-trace protein (β=−0.10, P=0.173) and beta-2 microglobulin (β=−0.30, P=0.344) BMS-777607 chemical structure levels. Models that included Cr, cystatin C, age and gender (Model 1) and Cr, cystatin C, beta-2 microglobulin, age and gender (Model 2) resulted

in the best fit to predict mGFR. Among 59 subjects with cirrhosis and ascites, the accuracy of Models 1 and 2 was significantly superior to conventional GFR-estimating equations (Table 1). Conclusions: Alternative renal function biomarkers, cystatin C, beta-2 microglobulin and beta-trace protein were not dependent on gender in patients with cirrhosis; whereas gender influenced serum Cr independent of mGFR. Models developed from subjects with cirrhosis that included serum Cr, cystatin C and beta-2 microglobulin

were more accurate predictors of mGFR than CrCl, eCrCl and conventional GFR equations among patients with ascites. Disclosures: Ayse L. Mindikoglu – Grant/Research Support: NIH/NIDD K5 K23 DK089008-04, Living Legacy Foundation of Maryland Charles Howell – Advisory Committees or Review Panels: Janssen, Inc,, Abb-Vie; Grant/Research Support: Gilead Sciences, Bristol Myer Squibb, Boehringer Ingelheim The following people have nothing to disclose: Thomas C. Dowling, Laurence S. Magder, Robert H. Christenson, Matthew R. Weir, Stephen L. Seliger, William R. Hutson Objectives: Cirrhosis of the liver is a disease that occurs worldwide. Current guidelines for clinical practice recommend the infusion of human albumin after large volume paracentesis. After inspecting the actual evidence behind this HM781-36B chemical structure recommendation, we decided to conduct a systematic review and meta-analysis to address whether or not, albumin infusion has an effect on mortality and morbidity in the context of large volume paracentesis. Methods: We performed a comprehensive search of large databases and abstract books of conference proceedings up to Dec. 31st 2013. We were finally able to include 21 randomized controlled trials, testing the infusion of human albumin against alternatives (vs. no treatment, vs. plasma expanders; vs.

vasoconstrictors) in HCC-free patients suffering from cirrhosis, totaling 1108 patients. We then analyzed them with regard to mortality, changes in plasma 上海皓元医药股份有限公司 renin activity (PRA), hyponatremia, renal impairment, recurrence of ascites with consequential re-admission into hospital and “additional complications” (bleeding from esophageal varices, infections, sepsis and multiple-organ dysfunction-syndrome). Additionally, we employed trial sequential analysis in order to calculate the number of patients required in controlled trials in order to be able to determine a statistically significant advantage of the administration of one agent over another with regard to mortality. Results: While the administration of albumin effectively prevents a rise in PRA as well as hyponatremia, strong clinical endpoints, especially mortality are not significantly improved.

Methods: To assess the application value and etiological structure of therapeutic ERCP in various biliary and pancreatic diseases, we analyze

retrospectively the pancreaticobiliary disease cases adopted ERCP diagnosis and treatment from January 1, 2005 to June 30, 2012 in the First Affiliated Hospital of Nanchang University, Jiangxi province. Results: There are 7902 success cases (98.06%) of 8058 in total which include 4321 cases of male (53.62%) and 3737 cases of female (46.38%). The average age is 58 years old of which the minimum is 9 and the maximum is 95. The 6.1% incidence of Barasertib complications contains 2 cases of deaths of severe acute pancreatitis and 1 cases of deaths of bleeding. Common causes for those as metioned above are calculus of bile duct (6220 cases, 77.19%), malignant stricture of the bile duct (729 cases, 9.05%), carcinoma of ampulla or duodenal papilla (319 cases, 3.96%), benign stenosis of the bile duct (287 Venetoclax cases, 3.56%), pancreatic cancer and chronic pancreatitis (161 cases, 2.00%), biliary ascariasis (104 cases, 1.29%), biliary fistula

(60 cases, 0.74%), anomalous pancreaticobiliary junction (58 cases, 0.72%), myxoma of pancreaticobiliary duct, congenital cystic dilatation of bile duct and the others MCE (74 cases, 0.92%). Conclusion: The therapeutic ERCP is safe and effective in biliary and pancreatic diseases. Common cause of pancreaticobiliary disease for ERCP diagnosis and treatment are calculus of bile duct, malignant stricture of the bile duct, carcinoma of ampulla or duodenal papilla, benign stenosis of the bile duct,

pancreatic cancer and chronic pancreatitis, biliary ascariasis, anomalous pancreaticobiliary junction, myxoma of pancreaticobiliary duct, congenital cystic dilatation of bile duct and the others. Key Word(s): 1. ERCP; 2. application value; 3. therapeutic; 4. Common cause; Presenting Author: GUO JING Additional Authors: LI MING, ZUO XIULI, LI CHANGQING, LIU JIANWEI, ZHANG QINGYUAN, LIYAN QING Corresponding Author: GUO JING, LIYAN QING Affiliations: Qilu Hospital Objective: probe-based confocal laser endomicroscopy (pCLE) is on the edge of entering daily practice in gastroenterological endoscopy. However, its performance in the field of esophageal squamous neoplasia are only rarely reported. Methods: METHODS: We recruited among patients referred for diagnostic esophagogastroduodenal endoscopy for pCLE imaging. Esophagus was scanned by WLE and I-SCAN, images from suspected esophageal lesions and control sites were interpreted and compared to histology.

However, the rebleeding rate is in prepare groups was about 28% because of the risk of laxatives stimulating the intestinal mucosa. This exceeds the non-preparing group. Conclusion: It seems not much necessary for intestinal preparation for CE in active bleeding situation, especially in emergency background. Laxatives will increase the rebleeding rate. And rebleeding will reduce the enthusiasm of the

patients and doctors which lead to the less positive finding. Key Word(s): 1. Obscure learn more GI bleeding; 2. Capsule endoscopy; 3. active GI bleeding; Presenting Author: LIYA HUANG Additional Authors: JINGJING WANG, XIAOJING GU, FANG HE, LI YANG Corresponding Author: LI YANG Affiliations: Department of Gastroenterology, Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia, BVD-523 purchase China Objective: Hui nation has four weeks of dawn-to-dusk fasting in the Muslim holy month of Ramandan in every year. During Ramadan, Muslims refrain from eating, drinking, smoking and sex from dawn to dusk. It is uncertain whether diet among Hui-Nation patients affects the prognosis of upper gastrointestinal bleeding (UGIB) admitted on Ramadan or no-Ramadan. The aim of this

study was to analyze the characteristics and the prognosis of UGIB according to Ramadan or no-Ramadan. Methods: We analyzed Hui-Nation patients’ admissions of UGIB in the affiliated hospital of Ningxia medical university from 1995 to 2012 MCE (a total of 638 admissions). Differences in mortality, the rate of

rebleeding, costs, and hospital stays between Hui-Nation patients on Ramadan and no-Ramadan were evaluated using regression models with adjustment for patients and clinical factors. Results: Ramadan admissions were associated with significantly higher hemorrhage rates than were no-Ramadan admissions among Hui-Nation patients. There were significant differences in bleeding between Ramadan and no-Ramadan. Hemorrhagic and erosive gastropathy and peptic ulcer are the main reason of UGIB in Ramadan. Peptic ulcer and esophageal varices are the main reason of UGIB in no-Ramadan. Ramadan admissions were associated with significantly higher hospitalization rates, blood transfusion and the rate of rebleeding (P < 0.05). There was no difference in UGIB mortality between Ramadan and no-Ramadan. Conclusion: Ramadan admission for UGIH is associated with increased longer lengths of stay, and higher in-patient charges, but no difference in mortality in Hui-Nation patients. Key Word(s): 1. Ramadan; 2. no-Ramadan; 3. Hui-Nation; 4. UGIB; Presenting Author: 雪 Corresponding Author: 雪 Affiliations: Objective: To investigate the risk factors of dual anti-platelet treatment related upper gastrointestinal hemorrhage. Methods: 2004 patients taking dual anti-platelet treatment for coronary heart disease were retrospectively analyzed and followed up.